While I usually pick all the games at once, due to the first Thursday night game I will just be posting my prediction for this game. Look later in the week for my other predictions and my fantasy studs.
The Bears defense has really struggled lately and with a west coast trip on a short week, I don't like their chances against Alex Smith and the 49ers improving passing game alongside Frank Gore running the ball.
My prediction is Bears 21 49ers 27
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